董  健

课题组主页:http://www.zs-guke.cn/Expert/ExpertDetail?id=10426

 

 

董健 博士,教授

DJ.jpg

 

19831989

19921996

19982003

19992002

 

20022003

20032005

 

20052014 

 

 

2014至今

上海医科大学

上海医科大学

复旦大学

日本国家工业技术研究所

复旦大学

复旦大学

 

复旦大学

 

 

复旦大学

医疗系本科

骨科学博士

副教授

组织工程中心

博士后

副教授、硕导

主任医师、教授、硕导

主任医师、教授、博导、骨科副主任

主任医师、教授、博导、骨科主任

 

 

研究领域 (Current Research Area)

JIAN DONG, Ph.D.

Professor

Email: dong.jian@zs-hospital.sh.cn

Tel.+86-13916930859

 

Œ 脊柱肿瘤的防治,脊柱退变疾病的防治,脊柱创伤

Prevention and treatment of spinal tumors, prevention and treatment of spinal degenerative diseases, spinal trauma  

 

 

 骨修复重建及骨诱导

Bone induction and reconstruction

Education and Employment

 

1983-1989

 

1992-1996

 

1998-2003

 

1999-2002

 

 

2002-2003

 

2003-2005

 

2005-2014

 

 

 

 

2014 till now

Master, Shanghai Medical University, China

Ph.D., Shanghai Medical University, China

Assoc. Professor, Fudan University, China

Postdoctor, Tissue Engineering center, National Industrial technology research institute, Japan

Assoc. Professor & Master's Supervisor, Fudan university

Professor & Master's Supervisor & Chief doctor, Fudan university

Professor & Chief doctor & Doctor's Supervisor & Assoc. Director of Department of Orthopedics, Zhongshan Hospital, Fudan university

Professor & Chief doctor & Chairman of Orthopaedics Zhongshan Hospital, Fudan university

 

Ž 骨相关生物材料

Biomaterials for bone tissue engineering

 

 

代表性论文 (Selected Publications)

 

1.         Chen Q, Cao L, Wang JL, Zhao H, Lin H*, Fan ZY, Dong J*. Improved Cell Adhesion and Osteogenesis with PLTGA (poly l-lactide, 1,3-trimethylene carbonate, and glycolide) Terpolymer by Gelatin-assisted Hydroxyapatite Immobilization for Bone Regeneration. Journal of Materials Chemistry B. 2018,6, 301-311.

2.       Jiang LB, Cao L, Ma YQ, Chen Q, Liang Y, Yuan FL, Li XL, Dong J*, Chen N. TIGAR mediates the inhibitory role of hypoxia on ROS production and apoptosis in rat nucleus pulposus cells. Osteoarthritis and cartilage. 2018; 26(1): 138-148.

3.       Cao L, Chen Q, Jiang LB, Dong Jian*, et al. Bioabsorbable self-retaining PLA /nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study. International Journal of Nanomedicine.  2017, 12(10): 7197-7205.

4.       Yuan FL, Xu MH, Li X, He X, Fang W, Jian Dong*. The Roles of Acidosis in Osteoclast Biology. Frontiers in Physiology. 2016 June; 6(1):1-8.

5.       Su D, Jiang L, Chen X, Dong J*, Shao Z*. Enhancing the Gelation and Bioactivity of Injectable Silk Fibroin Hydrogel with Laponite Nanoplatelets. ACS Appl Mater Interfaces. 2016 Apr 20;8(15):9619-28.

6.       Jiang LB, Cao L, Yin XF, Yasen M, Yishake M, Dong J*, Li XL. Activation of autophagy via Ca(2+)-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress. Cell Cycle. 2015 Mar 19;14(6):867-79.

7.       Zhao MD, Björninen M, Cao L, Wang HR, Pelto J, Li XQ, Hyttinen J, Jiang YQ, Kellomäki M, Miettinen S, Sándor GK, Seppänen R, Haimi S, Dong J*. Polypyrrole coating on poly-(lactide/glycolide)-β-tricalcium phosphate screws enhances new bone formation in rabbits. Biomedical Materials. 2015, 10(6):065016.

8.       Jiang LB, Cao L, Dong J*. Does autophagy activation really inhibit calcification of endplate chondrocytes under intermittent cyclic mechanical tension? Bone. 2015 Jun;75:240-1.

9.       Jiang LB, Zhang J, Dong J*. The potential negative effect of high-dose glucosamine on the chondrocyte: comment on the article by Caramés et al. Arthritis Rheumatol. 2014 Jan;66(1):228.

10.    Yuan FL, Wang HR, Yuan W, Zhao MD, Cao L, Duan PG, Jiang YQ, Li XL, Dong J*. Ovarian cancer G protein-coupled receptor 1 involved in acid-induced apoptosis of endplate chondrocytes inintervertebral discs. J Bone Miner Res. 2014; 29(1):67-77.

11.    Yuan FL, Wang RH, Cao L, Duan PG, Dong J*. New evidence of the role of the hypoxia-regulated pathway in nucleus pulposus cell survival: comment on the article by Hiyama et al. Arthritis Rheum. 2012; 64(3):940-941.

12.    Zhou J, Lin H, Dong J*, et al. The repair of large segmental bone defects in the rabbit with vascularized tissue engineered bone. Biomaterials. 2010; 31: 1171-1179.

13.    Dai WD, Naoki Kawazoe, Lin XT, Dong J, Chen GP. The influence of structural design of PLGA/collagen hybrid scaffolds in cartilage tissue engineering. Biomaterials. 2010;31:2141-2153.

14.    Wang Y, Uemura T, Dong J, et al. Application of Perfusion Culture Improves In Vitro and In Vivo Osteogenesis of Bone Marrow-Derived Osteoblatic Cells in Porous Ceramics Materials. Tissue Engineering, 2003; 9: 1205-1214.

15.    Dong J, Uemura T, Shirasaki Y, et al. Promotion of bone formation using highly pure porous β-TCP combined with mesenchymal stem cells. Biomaterials. 2002; 23: 4493-4502.

16.    Dong J, Kojima H, Uemura T, et al. Potenial osteogenesis in a novel porous hydroxyapatite combined with transplanted bone marrow derived osteoblastic cells. Bone. 2001; 28: S153.

 

 
           

 

主要奖励和荣誉 (Awards and Honors)

l  2017年国家卫生计生突出贡献中青年专家

l  2017年上海医学发展杰出贡献奖

l  2014年国家科技进步二等奖(第一完成人)

l  2013年上海市科技进步二等奖(第一完成人)

l  2011上海市领军人才荣誉称号

l  2011年上海市科技进步一等奖(第一完成人)

l  2010上海市医学领军人才 荣誉称号

 

学术任职 (Professional Services)

l  中华医学会骨科分会脊柱外科学组委员

l  中华医学会骨科分会骨质疏松学组委员

l  中华医学会上海分会骨科专委会常务委员;

l  中华医学会结核病学分会骨科专委会常务委员

l  中国医师协会骨科医师分会委员

l  中国医师协会骨科医师分会脊柱专家工作委员会委员

l  中国医师协会骨科医师分会骨肿瘤工作委员会委员

l  中国中西医结合骨伤科分会脊柱工作委员会副主任委员

l  中国中西医结合骨伤科分会骨质疏松工作委员会副主任委员

l  中国中西医结合学会上海分会骨伤科专业委员会主任委员

l  中国中西医结合学会骨科微创专业委员会副主任委员

l  SICOT中国部骨肿瘤学会常委

l  SICOT中国部脊柱外科学会常委

l  国家科学技术奖评委

l  上海市科技进步奖评审专家

l   863国家高技术研究发展计划评审专家

l  国家自然科学基金评审专家

l  Orthopaedic Surgery、中华外科杂志、中华骨科杂志、中华创伤杂志、中国脊柱脊髓杂志、中华创伤骨科杂志等期刊编委

l  BiomaterialsSpineEuropean spine journal ACS AMITissue EngineeringStem Cell Research & Therapy等期刊审稿专家