董  健

课题组主页:http://www.zs-guke.cn/Expert/ExpertDetail?id=10426

 

 

董健 博士,主任医师,教授   

Jian Dong MD, Ph.D.  Senior doctor, Professor

Tel: +86-21-64041990×3057

Email: dong.jian@zs-hospital.sh.cn

DJ.jpg

学习经历 (Education)

1983-1989

 

1992-1996

 

1999-2002

 

上海医科大学

Shanghai Medical University, China

上海医科大学

Shanghai Medical University, China

日本国立产业技术综合研究所组织工程中心

National Institute for Materials Science (NIMS), Japan

 

学士

M.D., B.S.

博士

Ph.D.

博士后

 Postdoctor

工作经历 (Employment Experience)

1989-1995

 

 

1995-1998

  

1998-2003

 

 

 

2003-2005

 

 

2005至今

 

 

 

2011至今

 

 

 

 2014至今

 

上海医科大学附属中山医院

Zhongshan Hospital, Shanghai Medical University, China

上海医科大学附属中山医院

Zhongshan Hospital, Shanghai Medical University, China

复旦大学(原上海医科大学)附属中山医院

Zhongshan Hospital, Fudan University, China

 

复旦大学附属中山医院

Zhongshan Hospital, Fudan University, China

 

复旦大学附属中山医院

Zhongshan Hospital, Fudan University, China

 

 

聚合物分子工程教国家重点实验室(复旦大学)

State Key Laboratory of Molecular Engineering of PolymersFudan University, China

 

 复旦大学附属中山医院

 Zhongshan Hospital, Fudan University, China

住院医师

Resident Doctor

 主治医师

Attending Doctor

副主任医师,副教授

Associate Senior Doctor, Associate Professor

主任医师,教授

Senior Doctor, Professor

骨科副主任,外科副主任

Vice Director of Orthopaedic Department, Vice Director of Surgical Department

项目负责人

 Principle Investigator

骨科科主任

Director of Orthopaedic Department

研究领域 (Research Field)

1         脊柱退变疾病的防治

Preventive Methods of Spinal Degenerative Diseases

 

2         骨修复重建及骨诱导

Restoration and Induction of Bones

 

3         骨相关生物材料

Biomedical Materials for Bone Regeneration

 

4  骨组织工程

Bone Tissue Engineering

 

已发表论文 (Publications)

1.        Jiang LB, Cao L, Dong J.Does autophagy activation really inhibit calcification of endplate chondrocytes under intermittent cyclic mechanical tension? Bone. 2015 Jun;75:240-1 (SCI, IF= 4.461Corresponding Author

2.        Yuan W, Che W, Jiang YQ, Yuan FL, Wang HR, Zheng GL, Li XL, Dong J. Establishment of intervertebral disc degeneration model induced by ischemic sub-endplate in rat tail. 2015 May 1;15(5):1050-9 (SCI, IF=2.8Corresponding Author

3.        Jiang LB, Cao L, Yin XF, Yasen M, Yishake M, Dong J, Li XL. Activation of autophagy via Ca(2+)-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress. Cell Cycle. 2015 Mar 19;14(6):867-79 (SCI, IF=5.003Corresponding Author

4.        Duan PG, Li RY, Jiang YQ, Wang HR, Zhou XG, Li XL, Wang YC, Dong J. Recurrent adamantinoma in the thoracolumbar spine successfully treated by three-level total en bloc spondylectomy by a single posterior approach. Eur Spine J. 2014 Oct 22. [Epub ahead of print] (SCI, IF=2.473Corresponding Author

5.        Feng-Lai Yuan, Ming-Dong Zhao, Li-Bo Jiang, Hui-Ren Wang, Lu Cao, Xiao-Gang Zhou, Xi-Lei Li, Jian Dong. Molecular Actions of Ovarian Cancer G Protein-Coupled Receptor 1 Caused by Extracellular Acidification in Bone. Int. J. Mol. Sci. 2014, 15, 22365-22373. (SCI, IF=2.339Corresponding Author

6.        Li X, Chen L, Lin H, Cao L, Cheng J, Dong J, Yu L, Ding J. Efficacy of Poly(D,L-Lactic Acid-co-Glycolic acid)-Poly(Ethylene Glycol)-Poly(D,L-Lactic Acid-co-Glycolic Acid) Thermogel As a Barrier to Prevent Spinal Epidural Fibrosis in a Postlaminectomy Rat Model. J Spinal Disord Tech. 2014 Nov 12. . (SCI, IF=1.888Corresponding Author

7.        Li J, Li XL, Zhou XG, Zhou J, Dong J. Surgical Treatment for Spinal Tuberculosis With Bilateral Paraspinal Abscess or Bilateral Psoas Abscess: One-stage Surgery. J Spinal Disord Tech. 2014 Dec;27(8):E309-14. (SCI, IF=1.888Corresponding Author

8.        Jiang LB, Jin YL, Wang HR, Jiang YQ, Dong J. Glucosamine protects nucleus pulposus cells and induces autophagy via the mTOR-dependent pathway. J Orthop Res. 2014 Nov;32(11):1532-42 (SCI, IF=2.972Corresponding Author

9.        Jiang LB, Yuan FL, Yin XF, Dong J. Responses and adaptations of intervertebral disc cells to microenvironmental stress: a possible central role of autophagy in the adaptive mechanism. Connect Tissue Res. 2014 Jul 25:1-11. (SCI, IF=1.982Corresponding Author

10.    Jiang YQ, Liu CC, Li RY, Wang WP, Ding H, Qi Q, Ta D, Dong J, Wang WQ.  Analysis of Apparent Integrated Backscatter Coefficient and Backscattered Spectral Centroid Shift in Calcaneus in vivo for the Ultrasonic Evaluation of Osteoporosis. Ultrasound Med Biol. 2014 Mar 15. pii: S0301-5629(13)01271-4. (SCI, IF=2.455Corresponding Author

11.    Jiang LB, Zhang J, Dong J. The potential negative effect of high-dose glucosamine on the chondrocyte: comment on the article by Caramés et al. Arthritis Rheumatol. 2014 Jan;66(1):228 (SCI, IF=7.87Corresponding Author

12.    Jiang LB, Yuan FL, Dong J. Comment on Park et al.: High glucose-induced oxidative stress promotes autophagy through mitochondrial damage in rat notochordal cells. Int Orthop. 2014 Mar;38(3):675-6. (SCI, IF=2.319Corresponding Author

13.    Wei Yuan, Aaron W. James, Greg Asatrian, Jia Shen, Janette N. Zara, Hai Jun Tian, Ronald K. Siu, Xinli Zhang, Jeffrey C. Wang, Jian Dong. NELL-1 based demineralized bone graft promotes rat spine fusionas compared to commercially available BMP-2 product. J Orthop Sci. 2013 Jul;18(4):646-57 (SCI, IF =0.96) Corresponding Author

14.    Yuan FL, Wang HR, Yuan W, Zhao MD, Cao L, Duan PG, Jiang YQ, Li XL, Dong J. Ovarian cancer G protein-coupled receptor 1 involved in acid-induced apoptosis of endplate chondrocytes inintervertebral discs. J Bone Miner Res. 2014; 29(1):67-77 (SCI, IF=6.13) Corresponding Author

15.    Yuan W, Zhao MD, Yuan FL, Che W, Duan PG, Liu Y, Dong J. Association of endothelin-1 expression and cartilaginous endplate degeneration in humans. PLoS One. 2013; 8(4):e60062 (SCI, IF=4.09) Corresponding Author

16.    Duan P, Pan Z, Cao L, He Y, Wang H, Qu Z, Dong J, Ding J. The effects of pore size in bilayered poly(lactide-co-glycolide) scaffolds on restoring osteochondral defects inrabbits. J Biomed Mater Res A. 2014; 102(1):180-192 (SCI, IF=2.63) Corresponding Author

17.    Hui-ren Wang, Xi-lei Li, MD, Jian Dong, et al. Skip-level anterior cervical discectomy and fusion with self-locking stand-alone PEEK cages for the treatment of two noncontiguous levels of cervical spondylosis. Journal of Spinal Disorders & Techniques. 2013; 26(7):E286-92.SCIIF=1.50Corresponding Author

18.    Cao Lu, Duan Pingguo, Hui-ren Wang, et al. Degradation and osteogenic potential of a novel poly(lactic acid)/nano-sized β-tricalcium phosphate scaffold. International Journal of Nanomedicine. 2012; 7: 5881-5888. (SCI, IF=3.13) Corresponding Author

19.    Cao Lu, Duan Pingguo, Li Xilei, et al. The biomechanical stability of a novel bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion device in single level ACDF sheep models. International Journal of Nanomedicine. 2012; 7: 5875-5880. (SCI, IF=3.13)  Corresponding Author

20.    Fang T, Wen J, Zhou J, Shao Z, Dong J. Poly (ε-caprolactone) coating delays vancomycin delivery from porous chitosan/β-tricalcium phosphate composites. J Biomed Mater Res B Appl Biomater. 2012;100B(7):1803-11. (SCI, IF=2.15)  Corresponding Author

21.    Zhou J, Fang TL, Wang YC, Dong J. The controlled release of vancomycin in gelatin/β-TCP composite scaffolds. Journal of Biomedical Materials Research: Part A. 2012; 100(9):2295-301. (SCI IF=3.04Corresponding Author

22.   Li C, Wang HR, Li XL, Zhou XG, Dong J. The relation between zoledronic acid infusion and interbody fusion in patients undergoing transforaminal lumbar interbody fusion surgery. Acta Neurochir. 2012; 154(4): 731-738. (IF 1.52) Corresponding Author

23.    Yuan FL, Wang RH, Cao L, Duan PG, Dong J. New evidence for the role of hypoxia-regulated pathway in nucleus pulposus cell survival. Arthritis Rheum. 2012; 64(3):940-941. ( IF 7.87Corresponding Author

24.    Jiang JL, Li YF, Fang TL, Zhou J, Li XL, Wang YC, Dong J. Vancomycin-loaded nano-hydroxyapatite pellets to treat MRSA-induced chronic osteomyelitis with bone defect in rabbits. Inflammation Research. 2012; 61(3): 207-215 (IF 2.11) Corresponding Author 

25.    Yiqun Ma, Xilei Li, Jian Dong. Is it useful to apply transpedicular intracorporeal bone grafting for thoracolumbar burst fractures: A Systematic Review. Acta Neurochirurgica. 2012,154, (12):2205-2213  (IF 1.52) Corresponding Author

26.    Hui-ren Wang, Sheng-sheng Cao, Xi-lei Li, et al. A Comparison between “Sandwich” and Conventional Methods of Repairing Spinal Dura Rupture. Orthop Surg. 2012 Nov;4(4):233-40  Corresponding Author

27.    Fang T, Dong J, Zhou X, et al. Comparison of Mini-open Anterior Corpectomy and Posterior Total en bloc Spondylectomy for Solitary Metastases of Thoracolumbar Spine. J Neurosurg Spine. 2012;17(4):271-9. (IF 1.53) Corresponding Author

28.    Li XL, Ma YQ, Dong J, Zhou XG, Li J. Retrospective analysis of treatment of thoracolumbar burst fracture using mono-segment pedicle instrumentation compared with short-segment pedicle instrumentation. Eur Spine J. 2012; 21(10): 2034-2042. (IF 1.97) Corresponding Author

29.    Jiang J, Li XL, Dong J. Plate-only open-door laminoplasty with fusion in treatment of multilevel degenerative cervical disease. Journal of Clinical Neuroscience. 2012; 19(6):804-809. (IF 1.25) Corresponding Author

30.    Yuan FL, Li X, Dong J, et al. IL-33: a promising therapeutic target for rheumatoid arthritis? Expert Opin Ther Targets. 2011. 15(5):529-534. (IF 3.72Corresponding Author

31.    Zhao MD, Zhou J, Dong J, et al. Repair of Bone Defect with Vascularized Tissue Engineered Bone Graft Seeded with Mesenchymal Stem Cells in Rabbits. Microsurgery. 2011.31(2):130-137. ( SCI 1.61Corresponding Author

32.    Zhou J, Fang TL, Dong J, et al. Silk coating on Poly (ε-caprolactone) microspheres for the delayed release of vancomycin. Journal of Microencapsulation. 2011. 28(2): 99-107. ( SCI 1.55) Corresponding Author

33.    Zhou J, Wang B, Dong J, et al. Instrumented transforaminal lumbar interbody fusion with single cage for the treatment of degenerative lumber disease. Archives of Orthopaedic and Trauma Surgery. 2011, 131(9):1239-45. (SCI 1.37) Corresponding Author

34. Che W, Li RY, Dong J, et al. Progress in diagnosis and treatment of cervical postoperative infection. Orthopaedic Surgery. 2011, 3 (3): 152–157. Corresponding Author

35. Zhou J, Li XL, Dong J, et al. Three-level anterior cervical discectomy and fusion with self-locking stand-alone polyetheretherketone cages. Journal of clinical neuroscience. 2011, 18(11):1505-9. (SCI 1.25) Corresponding Author

36. Zhou J, Xia Q, Dong J, et al. Comparison of stand-alone polyetheretherketone cages and iliac crest autografts for the treatment of cervical degenerative disc diseases. Acta Neurochirurgica. 2011, 153(1):115-122. (SCI 1.52) Corresponding Author

37. Zhou J, Lin H, Dong J, et al.The repair of large segmental bone defects in the rabbit with vascularized tissue engineered bone. Biomaterials 2010; 31: 1171-1179.SCI 7.40Corresponding Author

38. Dai WD, Naoki Kawazoe, Lin XT, Dong J, Chen GP. The influence of structural design of PLGA/collagen hybrid scaffolds in cartilage tissue engineering. Biomaterials. 2010;31:2141-2153.SCI 7.40Corresponding Author

39. Dai WD, Dong J, Chen GP. Application of low-pressure cell seeding system in tissue engineering. Bioscience Trends, 2009; 36: 216-219. SCI 0.97Corresponding Author

40. Dai WD, Dong J, Sun Y, et al. Stimulation of Osteogenic Activity in Mesenchymal Stem Cells by FK506. J. Biomed Mater Res. Part A. 2008; 86(1): 235-43SCI 2.63Corresponding Author

41. Dong J, Uemura T, Shirasaki Y, et al. Promotion of bone formation using highly pure porous β-TCP combined with mesenchymal stem cells. Biomaterials 2002; 23: 4493-4502. (SCI 7.40)

42. Dong J, Uemura T, Kikuchi M, Tanaka J, Tateishi T. Long-term durability of porous hydroxyapatite with low-pressure system to support osteogenesis of mesenchymal stem cells. Biomed Mater Eng. 2002; 12: 203-209. (SCI 0.922)

43. Dong J, Kojima H, Uemura T, et al. In Vivo Evaluation of a Novel Porous Hydroxyapatite to Sustain Osteogenesis of Transplanted Bone Marrow Derived Osteoblastic Cells. J Biomed Mater Res. 2001; 57: 208-216. (SCI 2.7)

44.    Dong J, Uemura T, Kojima H, et al. Application of low pressure system to sustain in vivo bone formation in osteoblast/porous hydroxyapatite composite. Mater Sci Eng C. 2001; 17: 37-43. (SCI 1.325)

45.    Dong J, Uemura T, Kojima H, et al. Stimulation of osteoblastic ability of bone marrow cells by in vitro application of FK506, a potent osteogenic agent. J. Bone and Miner Res. 2001; 16: S496. (SCI 6.37)

46.    Dong J, Kojima H, Uemura T, et al. Potenial osteogenesis in a novel porous hydroxyapatite combined with transplanted bone marrow derived osteoblastic cells. Bone 2001; 28: S153. (SCI, 4.02)

47.    Uemura T, Nemoto A, Liu YK, Kojima H, Dong J. Osteopontin involvement in bone remodeling and its effect on in vivo osteogenic potential of bone marrow-derived osteoblasts/porous hydroxyapatite constructs. Materials science and engineering C-Bomimetic and supramolecular Systems 2001; 17: 33-36. (SCI, 1.325)

48.    王会仁, 李熙雷, 周晓岗, 林红, 董健. 酶预消化组织块贴壁法培养人退变椎间盘髓核细胞. 中华创伤杂志, 2012,11(8):1032-1036.通讯作者

49.    段平国, 董健. 双层支架材料构建组织工程骨软骨修复关节软骨缺损.中华创伤杂志,2012,282):189-192通讯作者

50.    李熙雷,车武,董健,等. 经伤椎单节段椎弓根螺钉固定治疗胸腰椎爆裂骨折的生物力学研究. 中华创伤骨折杂志,2012,14(3):225-227. 通讯作者

51.    李超, 方涛林, 董健. 影响人工骨载药微球发作用的因素.中国组织工程研究杂志, 2011,15(3):515-518. 通讯作者

52.    赵明东,潘志宏,董健,等. 桡骨缺损模型:骨缺损标准尺寸的确立.中国组织工程研究杂志,2011,15(2):213-218. 通讯作者

53.    董健.含抗生素的人工骨替代材料相关问题.中国组织工程研究与临床康复.2009,13(21):416441764180. 通讯作者

54.    戴文达, 林红, 董健,.人骨髓间充质干细胞结合多孔β-TCP构建生物相容性人工骨. 中国生物医学工程学报, 2009, 28: 108-116.  通讯作者

55.    戴文达, 方涛林, 李熙雷, 林红, 董健, 陈峥嵘. 人骨髓间充质干细胞的分离培养、多向分化与鉴定. 复旦学报, 2008(35)3:448-452. 通讯作者

56.    林红, 董健, 戴文达,. 间充质干细胞与其诱导血管内皮细胞联合种植构筑血管化组织工程骨修复兔大段骨缺损. 中华医学杂志, 2008, 88: 337-341.  通讯作者

57.    李云飞, 方涛林, 董健. 载万古霉素纳米羟基磷灰石对耐甲氧西林金黄色葡萄球菌慢性骨髓炎兔骨缺损的修复. 中国组织工程研究与临床修复, 2008; 12(23):4422-6. 通讯作者

58.    董健, 戴文达, 方涛林,. FK506诱导的骨髓间充质干细胞成骨细胞分化和体内骨形成.中华医学杂志, 2007;87(3):190-4.  通讯作者

59.    李云飞,戴文达,董健,.兔耐甲氧西林金黄色葡萄球菌慢性骨髓炎模型.中华实验外科杂志,2007,24:503-504. 通讯作者

60.    董健,方涛林,孙源,. FK506对骨髓间充质干细胞体外成骨活性的诱导.中华创伤杂志, 2006; 22: 775-8. 通讯作者

61.    孙源, 林红,董健,. 联合培养时诱导的内皮细胞对自体骨髓基质干细胞成骨作用的影响. 中华创伤骨科杂志, 2006; 8(10): 913-23.  通讯作者

62.    董健,方涛林,孙源,. FK506对骨髓间充质干细胞体外成骨活性的诱导.中华创伤杂志, 2006; 22: 775-8. 通讯作者

63.    孙源, 董健. 诱导兔骨髓间充质干细胞成为内皮细胞. 中国矫形外科杂志, 2005; 14: 56-57. 通讯作者

 

主要奖励和荣誉 (Awards and Honors)

1. 2014国家科技进步二等奖(第一完成人)

Awarded as “The First Prize for National ScientificandTechnologicalProgress, China”  (The first of the participants involved)

2. 2013上海市科技进步二等奖(第一完成人)

Awarded as “The Second Prize for ScientificandTechnologicalProgress of Shanghai, China”  (The first of the participants involved)

3. 2012上海市医学科技三等奖(第一完成人)

Awarded as “The Third Prize for Medical ScientificandTechnologicalProgress of Shanghai, China” (The first of the participants involved)

4. 2011上海市领军人才荣誉称号

Awarded as “Outstanding Academic Leader of Shanghai, China

5. 2011上海市科技进步一等奖(第一完成人)

Awarded as “The First Prize for ScientificandTechnologicalProgress of Shanghai, China”  (The first of the participants involved)

6. 2010上海市医学领军人才荣誉称号

Awarded as “Outstanding Medical Academic Leader of Shanghai, China

7. 2010中国实验动物学会科学技术三等奖(第一完成人)

Awarded as “The Third Prize in Science and Technology of Chinese Association for Laboratory Animal Sciences” (The first of the participants involved)

8. 2008上海市医学科技奖二等奖(第一完成人)

Awarded as “The Second Prize for Medical ScientificandTechnologicalProgress of Shanghai, China” (The first of the participants involved)

9. 2007上海市优秀学科带头人荣誉称号

Subject Chief Scientist of Shanghai, China

10.     第二十二届上海市优秀发明银奖

 

 Silver Medal of the Twenty-second Outstanding Invention Award of Shanghai, China