陈国颂

课题组主页:http://www.polymer.fudan.edu.cn/polymer/research/CGSJM/CN/content.aspx?info_lb=28&flag=4

 

陈国颂 博士

 

陈国颂.jpg

 

1997-2001

2001-2006

2006-2008

 

2009-2011

2011-2014

2014 至今

 

南开大学

南开大学

美国爱荷华州立大学化学系

复旦大学

复旦大学

复旦大学

 

化学学士

物理化学博士

有机化学博士后

 

讲师

副教授

教授、博士生导师

 

研究领域 (Current Research Area)

Guosong Chen, Ph.D.

Tel: +86-21-31244275

Email: guosong@fudan.edu.cn

 

Œ -蛋白相互作用诱导的蛋白质自组装

Self-assembly of proteins induced by carbohydrate-protein interaction

 

 含糖组装体的免疫学功能

Immunological functions of macromolecular self-assembly based on carbohydrates

Education and Employment

 

1997-2001

2001-2006

2006-2008

 

2009 till now

B.S., Nankai University, China

Ph.D., Nankai University, China

Postdoc, Department of Chemistry, Iowa State Univerisity, United States

Fudan University

 

Ž 糖化学驱动的大分子组装

Macromolecular Self-assembly driven by carbohydrate chemistry

 

代表性论文 (Selected Publications)

 

l  Yufei Zhang, Libin Wu, Zhen Li, Weiyi Zhang, Feifei Luo, Yiwei Chu, Guosong Chen*, “Glycocalyx-Mimicking Nanoparticles Improve Anti-PD-L1 Cancer Immunotherapy through Reversion of Tumor-Associated Macrophages” Biomacromolecules 2018, 19, x.

l  Libin Wu, Yufei Zhang, Zhen Li, Guang Yang, Zdravko Kochovski, Guosong Chen*, Ming Jiang, “"Sweet" Architecture-Dependent Uptake of Glycocalyx-Mimicking Nanoparticles Based on Biodegradable Aliphatic Polyesters by Macrophages” J. Am. Chem. Soc., 2017, 139, 14684-14692.

l  Wei Zheng, Guang Yang, Nannan Shao, Li-Jun Chen, Bo Ou, Shu-Ting Jiang, Guosong Chen*, Haibo Yang*, “CO2 Stimuli-Responsive, Injectable Block Copolymer Hydrogels Cross-linked by Discrete Organoplatinum(II) Metallacycles via Stepwise Post-Assembly Polymerization”, J. Am. Chem. Soc., 2017, 139, 13811-13820.

l  Guang Yang, Hong-ming Ding, Zdravko Kochovski, Rongting Hu, Yan Lu, Yu-qiang Ma*, Guosong Chen*, Ming Jiang “Highly ordered self-assembly of native proteins into 1D, 2D and 3D structures modulated by a tether length of inducing ligands”, Angew. Chem. Int. Ed. 2017, 56, 10691-10695.

l  Yu Zhao, Yufei Zhang, Changchun Wang, Guosong Chen*, Ming Jiang, “Role of Protecting Groups in Synthesis and Self-Assembly of Glycopolymers”, Biomacromolecules 2017, 18, 568-575.

l  Zhen Li, Liang Sun, Yufei Zhang, Andrew P Dove, Rachel K. O'Reilly*, Guosong Chen*, “Shape Effect of Glyco-Nanoparticles on Macrophage Uptake and Immune Response”, ACS Macro Lett., 2016, 5, 1059-0164.

l  Yijiang Liu, Yufei Zhang, Zheyu Wang, Jue Wang, Kongchang Wei, Guosong Chen*, Ming Jiang, “Building Nanowires from Micelles: Hierarchical Self-assembly of Alternating Amphiphilic Glycopolypeptide Brushes with Pendants of High-Mannose Glycodendron and Oligophenylalanine”, J. Am Chem. Soc. 2016, 138, 12387-12394.

l  Guang Yang, Libin Wu, Guosong Chen*, Ming Jiang, “Precise Protein Assembly to Array Structures”, Chem. Commun. 2016, 52, 10595-10605.

l  Zhongwei Ji, Junfang Li, Guosong Chen*, Ming Jiang, “Fate of Host-Stabilized Charge Transfer Complexation Based on Cucurbit[8]uril: Inducing Cyclization of PNIPAM and Dissociation in Self-Assembly of the Cyclic Polymer”, ACS Macro Lett. 2016, 5, 588-592.

l  Wei Zheng, Li-Jun Chen, Guang Yang, Bin Sun, Xu Wang, Bo Jiang, Guang-Qiang Yin, Li Zhang, Xiaopeng Li, Minghua Liu, Guosong Chen*, Haibo Yang*, “Construction of Smart Supramolecular Polymeric Hydrogels Cross-linked by Discrete Organoplatinum(II) Metallacycles via Post-Assembly Polymerization”, J. Am. Chem. Soc., 2016, 138, 4927-4937.

l  Guang Yang, Xiang Zhang, Zdravko Kochovski, Yufei Zhang, Bin Dai, Fuji Sakai, Lin Jiang, Yan Lu, Matthias Ballauff, Xueming Li, Cong Liu*, Guosong Chen*, Ming Jiang, “Precise and Reversible Protein-Microtubule-Like Structure with Helicity Driven by Dual Supramolecular Interactions”, J. Am. Chem. Soc., 2016, 138, 1932-1937.

l  Yijiang Liu, Yu Kang, Jue Wang, Zheyu Wang, Guosong Chen*, Ming Jiang, “Sequence-defined peptidocopolymers: the effect of small molecular linkers”, Biomacromolecules 2015, 16, 3995-4003.

l  Mingchang Lin, Yufei Zhang, Guosong Chen*, Ming Jiang, “Supramolecular glyco-nanoparticles toward immunological applications”, Small 2015, 11, 6065-6070.

l  Xiulong Wu, Lu Su, Guosong Chen*, Ming Jiang, “Deprotection-induced micellization of glycopolymers: control of kinetics and morphologies”, Macromolecules 2015, 48, 3705-3712.

l  Lu Su, Weiyi Zhang, Xiulong, Wu, Yufei Zhang, Xi Chen, Guangwei Liu, Guosong Chen*, Ming Jiang, “Glycocalyx-mimicking nanoparticles for stimulation and polarization of macrophages via specific interactions”, Small 2015, 11, 4191-4200.

l  Fuji Sakai, Guang Yang, Manfred S. Weiss, Yijiang Liu, Guosong Chen*, Ming Jiang*, “Protein Crystalline Frameworks with Controllable Interpenetration Directed by Dual Supramolecular Interactions” Nature Communications 2014, 5, 4634-9782.

l  Yu Zhao, Fuji Sakai, Lu Su, Yijiang Liu, Kongchang Wei, Guosong Chen*, Ming Jiang*, “Progressive Macromolecular Self-assembly: from Biomimetic Chemistry to Bio-inspired Materials” Adv. Mater. 2013, 25, 5215–5256.

l  Mingchang Lin, Guosong Chen*, Ming Jiang, “Glyco-stereoisomerism effect on hydrogelation of interacting polymers via dynamic covalent bond” Chem. Commun. 2014, 50, 9779-9782.

l  Kongchang Wei, Jun Li, Guosong Chen*, Ming Jiang, “Dual molecular recognition leading to a protein-polymer conjugate and further self-assembly” ACS Macro Lett. 2013, 2, 278-283.

 

学术组织任职

 

l  Associate Editor of ACS Macro Letters

l  Fellow of Royal Society of Chemitry (FRSC)

l  中国化学会第30届高分子学科委员会委员

l  《中国科学化学》青年编委

 

 

主要奖励和荣誉 (Awards and Honors)

 

l  2018 ACS PMSE Young Investigator Award

l  冯新德高分子奖(Elsevier杂志社)

l  第十八届诺贝尔奖获得者大会参加奖(国家自然科学基金委和德国DFG联合选拔)

Participation award of 18th Meeting of Nobel Price Winners in Chemistry at Lindau, Lake of Constance, Germany, 2006.